Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk …

W Wang, H Zhao, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Uveal melanoma (UVM) is the most invasive intraocular malignancy in adults
with a poor prognosis. Growing evidence revealed that immune-related gene is related to …

Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma

B Yang, Y Fan, R Liang, Y Wu, A Gu - BMC ophthalmology, 2023 - Springer
Background To identify an immune-related prognostic signature and find potential
therapeutic targets for uveal melanoma. Methods The RNA-sequencing data obtained from …

Identification and validation of an immune-relevant risk signature predicting survival outcome and immune infiltration in uveal melanoma

X Sun, Q Li, G Xu - International Ophthalmology, 2023 - Springer
Purpose The current study aimed to reveal a novel immune-related signature to evaluate
immune infiltration status and the survival outcome for patients with uveal melanoma (UM) …

Construction and validation of a novel immunosignature for overall survival in uveal melanoma

C Gu, X Gu, Y Wang, Z Yao, C Zhou - Frontiers in Cell and …, 2021 - frontiersin.org
Objectives Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults, and immune infiltration plays a crucial role in the prognosis of UM. This study aimed …

Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma

F Xia, Z Yu, A Deng, G Gao - Experimental Biology and …, 2022 - journals.sagepub.com
Immunotherapy is the most promising treatment for uveal melanoma patients with
metastasis. Tumor microenvironment plays an essential role in tumor progression and …

Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma

C Zhang, J Xiao, L Fa, F Jiang, H Jiang, L Zhou… - BMC …, 2023 - Springer
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however,
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …

Identification of survival-related genes and a novel gene-based prognostic signature involving the tumor microenvironment of uveal melanoma

S Lei, Y Zhang - International Immunopharmacology, 2021 - Elsevier
Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults
and almost fifty percent of patients subsequently develop systemic metastases usually …

Integration of bulk RNA sequencing and single-cell RNA sequencing to reveal uveal melanoma tumor heterogeneity and cells related to survival

G Gao, A Deng, S Liang, S Liu, X Fu, X Zhao… - Frontiers in …, 2022 - frontiersin.org
Molecular classification based on transcriptional characteristics is often used to study tumor
heterogeneity. Human cancer has different cell populations with distinct transcription in …

A comprehensive prognostic and immunological analysis of a six-gene signature associated with glycolysis and immune response in uveal melanoma

J Liu, J Lu, W Li - Frontiers in immunology, 2021 - frontiersin.org
Uveal melanoma (UM) is a subtype of melanoma with poor prognosis. This study aimed to
construct a new prognostic gene signature that can be used for survival prediction and risk …

Identification of immune cell infiltration landscape and their prognostic significance in uveal melanoma

H Zhao, Y Chen, P Shen, L Gong - Frontiers in Cell and …, 2021 - frontiersin.org
Uveal melanoma (UVM) is the most common primary intraocular cancer in adults. Increasing
evidence has demonstrated that immune cell infiltration (ICI) is crucial in predicting patient …