Abstract Class I MHC complexes (MHC I) are essential in mediating immune response. The
transport of antigenic peptides (TAP) to MHC I and the stable expression of MHC I on the cell …

The genes of the transporter associated with antigen processing (Tap)-1, and the low
molecular weight peptide (Lmp)-2, are crucial for class I major histocompatibility complex …

Transporter associated with Ag processing 1 and low molecular mass polypeptide 2 (LMP2)
are essential for class I MHC function and share a common bidirectional promoter. In murine …

In accordance with the key role of MHC class I molecules in the adaptive immune response
against viruses, they are expressed by most cells, and their expression can be enhanced by …

Presentation of intracellularly derived antigenic peptides to T cells requires their assembly
together with MHC class I molecules in the endoplasmic reticulum (ER). Such peptides are …

Interferon (IFN)-γ and IFN-α/β induction of the transporter associated with antigen
processing-1 (TAP1) promoter was compared in HeLa cells and endothelial cells (ECs). In …

IFN-ε is a unique type I IFN whose constitutive expression in lung, brain, small intestine, and
reproductive tissues is only partially understood. Our previous observation that …

Transporter in Ag processing-1 (TAP-1, previously called PSF-1 or Ring-4) is an MHC-
encoded gene product that is required for efficient association of intracellular peptide Ag …

Within the adaptive immune system the transporter associated with antigen processing
(TAP) plays a pivotal role in loading of peptides onto major histocompatibility (MHC) class I …

The components of the antigen processing machinery, low molecular mass polypeptide
(LMP) 2 and transporter associated with antigen processing (TAP) 1, are encoded by closely …