High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment

B Naik, N Gupta, R Ojha, S Singh, VK Prajapati… - International Journal of …, 2020 - Elsevier
The present-day world is severely suffering from the recently emerged SARS-CoV-2. The
lack of prescribed drugs for the deadly virus has stressed the likely need to identify novel …

Discovery of potent SARS-CoV-2 inhibitors from approved antiviral drugs via docking and virtual screening

S Chtita, A Belhassan, A Aouidate… - … chemistry & high …, 2021 - ingentaconnect.com
Background: Coronavirus Disease 2019 (COVID-19) pandemic continues to threaten
patients, societies and healthcare systems around the world. There is an urgent need to …

[HTML][HTML] The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins

P Singh, SS Chauhan, S Pandit, M Sinha… - Journal of traditional and …, 2022 - Elsevier
Background The severe acute respiratory syndrome-2019 has affected more than 190
million people around the world and caused severe crises throughout the globe. Due to …

Exploration of natural compounds with anti-SARS-CoV-2 activity via inhibition of SARS-CoV-2 Mpro

S Bharadwaj, A Dubey, U Yadava… - Briefings in …, 2021 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a dreaded pandemic in lack of specific …

Discovery of Natural Bisbenzylisoquinoline Analogs from the Library of Thai Traditional Plants as SARS-CoV-2 3CLPro Inhibitors: In Silico Molecular Docking, Molecular …

N Khamto, K Utama, S Tateing… - Journal of Chemical …, 2023 - ACS Publications
The emergence of SARS-CoV-2 in December 2019 has become a global issue due to the
continuous upsurge in patients and the lack of drug efficacy for treatment. SARS-CoV-2 …

Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target

Umesh, D Kundu, C Selvaraj, SK Singh… - Journal of …, 2021 - Taylor & Francis
Abstract The 2019-novel coronavirus (nCoV) has caused a global health crisis by causing
coronavirus disease-19 (COVID-19) pandemic in the human population. The unavailability …

Computational determination of potential multiprotein targeting natural compounds for rational drug design against SARS-COV-2

ZT Muhseen, AR Hameed, HMH Al-Hasani, S Ahmad… - Molecules, 2021 - mdpi.com
SARS-CoV-2 caused the current COVID-19 pandemic and there is an urgent need to
explore effective therapeutics that can inhibit enzymes that are imperative in virus …

Anti-HIV-drug and phyto-flavonoid combination against SARS-CoV-2: a molecular docking-simulation base assessment

SS Swain, SR Singh, A Sahoo… - Journal of Biomolecular …, 2022 - Taylor & Francis
At the health emergence, no such potent prophylactic therapy is available to control the
deadly emerged Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) …

[HTML][HTML] Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics

MA Alamri, A Altharawi, AB Alabbas… - Arabian Journal of …, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has affected almost every country in the
world by causing a global pandemic with a high mortality rate. Lack of an effective vaccine …

In silico Screening of Natural Phytocompounds Towards Identification of Potential Lead Compounds to Treat COVID-19

M Sankar, B Ramachandran, B Pandi… - Frontiers in molecular …, 2021 - frontiersin.org
COVID-19 is one of the members of the coronavirus family that can easily assail humans. As
of now, 10 million people are infected and above two million people have died from COVID …