The formation of a hollow lumen in a formerly solid mass of cells is a key developmental
process whose dysregulation leads to diseases of the kidney and other organs. Hydrostatic …

Many organ functions rely on epithelial cavities with particular shapes. Morphogenetic
anomalies in these cavities lead to kidney, brain or inner ear diseases. Despite their …

How vascular tubes build, maintain and adapt continuously perfused lumens to meet local
metabolic needs remains poorly understood. Recent studies showed that blood flow itself …

The ability to form epithelial lumina is a central architectural characteristic of virtually all
organs and indispensable for their function. Ontogenetically, the kidney is one of the best …

Lumen morphogenesis results from the interplay between molecular pathways and
mechanical forces. In several organs, epithelial cells share their apical surfaces to form a …

The de novo formation of secretory lumens plays an important role during organogenesis. It
involves the establishment of a cellular apical pole and the elongation of luminal cavities …

The formation of polarized epithelial tubules is a hallmark of kidney development. One of the
fundamental principles in tubulogenesis is that epithelia coordinate the polarity of individual …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …

Lumens, liquid-filled cavities surrounded by polarized tissue cells, are elementary units
involved in the morphogenesis of organs. Theoretical modeling and computations, which …

Many organs consist of tubes of epithelial cells enclosing a central lumen. How the space of
this lumen is generated is a key question in morphogenesis. Two predominant mechanisms …