Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production
Mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2
can lead to R (−)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site …
can lead to R (−)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site …
[HTML][HTML] The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization
Monoallelic point mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) and its
mitochondrial homolog IDH2 can lead to elevated levels of 2-hydroxyglutarate (2HG) in …
mitochondrial homolog IDH2 can lead to elevated levels of 2-hydroxyglutarate (2HG) in …
[HTML][HTML] 2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase …
G Jin, ZJ Reitman, I Spasojevic, I Batinic-Haberle… - PloS one, 2011 - journals.plos.org
Background Gliomas frequently contain mutations in the cytoplasmic NADP+-dependent
isocitrate dehydrogenase (IDH1) or the mitochondrial NADP+-dependent isocitrate …
isocitrate dehydrogenase (IDH1) or the mitochondrial NADP+-dependent isocitrate …
Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism
AR Rendina, B Pietrak, A Smallwood, H Zhao, H Qi… - Biochemistry, 2013 - ACS Publications
The human, cytosolic enzyme isocitrate dehydrogenase 1 (IDH1) reversibly converts
isocitrate to α-ketoglutarate (αKG). Cancer-associated somatic mutations in IDH1 result in a …
isocitrate to α-ketoglutarate (αKG). Cancer-associated somatic mutations in IDH1 result in a …
Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development
L Dang, SSM Su - Annual review of biochemistry, 2017 - annualreviews.org
The identification of heterozygous mutations in the metabolic enzyme isocitrate
dehydrogenase (IDH) in subsets of cancers, including secondary glioblastoma, acute …
dehydrogenase (IDH) in subsets of cancers, including secondary glioblastoma, acute …
[HTML][HTML] R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis
The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have
lost their normal catalytic activity and gained a novel function to produce R-2 …
lost their normal catalytic activity and gained a novel function to produce R-2 …
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas
G Jin, ZJ Reitman, CG Duncan, I Spasojevic… - Cancer research, 2013 - AACR
Point mutations at Arg132 of the cytoplasmic NADP+-dependent isocitrate dehydrogenase 1
(IDH1) occur frequently in gliomas and result in a gain of function to produce the …
(IDH1) occur frequently in gliomas and result in a gain of function to produce the …
[HTML][HTML] The mechanisms of IDH mutations in tumorigenesis
Tumor-associated mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2)
genes result in the loss of normal catalytic activity, the production of α-ketoglutarate (α-KG) …
genes result in the loss of normal catalytic activity, the production of α-ketoglutarate (α-KG) …
What a difference a hydroxyl makes: mutant IDH,(R)-2-hydroxyglutarate, and cancer
JA Losman, WG Kaelin - Genes & development, 2013 - genesdev.cshlp.org
Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells
K Smolková, A Dvořák, J Zelenka, L Vítek… - The international journal …, 2015 - Elsevier
Mitochondrial NADPH-dependent isocitrate dehydrogenase, IDH2, and cytosolic IDH1,
catalyze reductive carboxylation of 2-oxoglutarate. Both idh2 and idh1 monoallelic mutations …
catalyze reductive carboxylation of 2-oxoglutarate. Both idh2 and idh1 monoallelic mutations …