Abstract Background and Aims Chloride, potassium and sodium are electrolytes that play a
key role in several physiological processes. To date, the genetic factors underlying their …

Genome-wide association studies (GWAS), now celebrating a decade and a half of
successful genomic discovery, are the main study design applied at the population scale to …

Abstract Background and Aims Genetic insights are becoming increasingly influential in the
understanding and treatment of various kidney diseases (KD). Hundreds of genes …

With increasing incidence and a prev-alence of> 10% among adults worldwide, chronic
kidney disease (CKD) represents a major public health issue. 1 CKD can lead to metabolic …

Background Chronic kidney disease (CKD) is common and disproportionally burdens
United States ethnic minorities. Its genetic determinants may differ by disease severity and …

Background Urine biomarkers, such as creatinine, microalbumin, potassium and sodium are
strongly associated with several common diseases including chronic kidney disease …

The handling of electrolytes by the kidney is essential for homeostasis. However, the
heritability of these processes, the first step in gene discovery, is poorly known. To help …

Background: GWASs have identified hundreds of common genetic variants associated with
chronic kidney disease (CKD), but the burden of rare loss-of-function (LoF) or …

Chronic kidney disease (CKD) patients have many affected physiological pathways.
Variations in the genes regulating these pathways might affect the incidence and …

Purpose of review: Genetic testing can improve diagnostic precision in some patients with
end-stage renal disease (ESRD) providing the potential for targeted therapy and improved …