[HTML][HTML] A novel therapeutic peptide blocks SARS-CoV-2 spike protein binding with host cell ACE2 receptor
Abstract Background and Objective Coronavirus disease 2019 is a novel disease caused by
the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first detected …
the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first detected …
Computational insights into differential interaction of mammalian angiotensin-converting enzyme 2 with the SARS-CoV-2 spike receptor binding domain
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent
of the COVID-19 pandemic. Angiotensin-converting enzyme 2 (ACE2) has been identified as …
of the COVID-19 pandemic. Angiotensin-converting enzyme 2 (ACE2) has been identified as …
Why does the novel coronavirus spike protein interact so strongly with the human ACE2? A thermodynamic answer
J de Andrade, PFB Gonçalves, PA Netz - ChemBioChem, 2021 - Wiley Online Library
The SARS‐CoV‐2 pandemic is the biggest health concern today, but until now there is no
treatment. One possible drug target is the receptor binding domain (RBD) of the coronavirus' …
treatment. One possible drug target is the receptor binding domain (RBD) of the coronavirus' …
Comparative molecular dynamics study of the receptor-binding domains in SARS-CoV-2 and SARS-CoV and the effects of mutations on the binding affinity
Here, we report on a computational comparison of the receptor-binding domains (RBDs) on
the spike proteins of severe respiratory syndrome coronavirus‐2 (SARS-CoV-2) and SARS …
the spike proteins of severe respiratory syndrome coronavirus‐2 (SARS-CoV-2) and SARS …
Impact of South African 501. V2 variant on SARS-CoV-2 spike infectivity and neutralization: a structure-based computational assessment
Abstract Motivation The SARS-CoV-2 variants emerging from South Africa (501. V2) and the
UK (B. 1.1. 7) necessitate rapid assessment of the effects of the corresponding amino acid …
UK (B. 1.1. 7) necessitate rapid assessment of the effects of the corresponding amino acid …
Omicron binding mode: Contact analysis and dynamics of the omicron receptor-binding domain in complex with ACE2
On 26 November 2021, the WHO classified the Omicron variant of the SARS-CoV-2 virus (B.
1.1. 529 lineage) as a variant of concern (VOC)(COVID-19 Variant Data, Department of …
1.1. 529 lineage) as a variant of concern (VOC)(COVID-19 Variant Data, Department of …
[HTML][HTML] Identifying promising druggable binding sites and their flexibility to target the receptor-binding domain of SARS-CoV-2 spike protein
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
crucial for viral infection. The interaction of its receptor-binding domain (RBD) with the …
crucial for viral infection. The interaction of its receptor-binding domain (RBD) with the …
[HTML][HTML] Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
caused millions of infections and deaths worldwide since its discovery in late 2019 in …
caused millions of infections and deaths worldwide since its discovery in late 2019 in …
[HTML][HTML] Computational biophysical characterization of the SARS-CoV-2 spike protein binding with the ACE2 receptor and implications for infectivity
SARS-CoV-2 is a novel highly virulent pathogen which gains entry to human cells by
binding with the cell surface receptor–angiotensin converting enzyme (ACE2). We …
binding with the cell surface receptor–angiotensin converting enzyme (ACE2). We …
[HTML][HTML] Conformational changes of the receptor binding domain of SARS-CoV-2 spike protein and prediction of a B-cell antigenic epitope using structural data
S Khare, M Azevedo, P Parajuli… - Frontiers in Artificial …, 2021 - frontiersin.org
COVID-19, the illness caused by the SARS-CoV-2 virus, is now a worldwide pandemic with
mortality in hundreds of thousands as infections continue to increase. Containing the spread …
mortality in hundreds of thousands as infections continue to increase. Containing the spread …