COVID-19 (Coronavirus Disease-2019), a respiratory disease caused by the novel virus
strain, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), an enveloped …

Ubiquitin signaling is essential for immunity to restrict pathogen proliferation. Due to its
enormous impact on human health and the global economy, intensive efforts have been …

Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), poses an unprecedented threat to human health …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), has seriously threatened global public health. Severe COVID-19 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …

SARS-COV-2 infection-induced excessive or uncontrolled cytokine storm may cause injury
of host tissue or even death. However, the mechanism by which SARS-COV-2 causes the …

Melanoma differentiation-associated gene-5 (MDA5) acts as a cytoplasmic RNA sensor to
detect viral dsRNA and mediates antiviral innate immune responses to infection by RNA …

Suppression of type I interferon (IFN) response is one pathological outcome of the infection
of highly pathogenic human coronaviruses. To effect this, severe acute respiratory syndrome …

Understanding the molecular basis of innate immune evasion by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is an important consideration for designing the next …

Patients with severe coronavirus disease 2019 tend to have high levels of proinflammatory
cytokines, which eventually lead to cytokine storm and the development of acute respiratory …