The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …

Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …

Using expression profiles from postmortem prefrontal cortex samples of 624 dementia
patients and non‐demented controls, we investigated global disruptions in the co‐regulation …

Classical biological methods involving analyses of one or several genes have been the
mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by
amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells …

Aging is regarded as a major risk factor for neurodegenerative diseases. Thus, a better
understanding of the similarities between the aging process and neurodegenerative …

It is well-established that widespread transcriptional changes accompany the onset and
progression of Alzheimer's disease. Because of the multifactorial nature of this …

Abstract Background Transcriptional studies suggest Alzheimer's disease (AD) involves
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …

The role of different cell types and their interactions in Alzheimer's disease (AD) is a complex
and open question. Here, we pursued this question by assembling a high-resolution cellular …