To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …

Although complex inflammatory-like alterations are observed around the amyloid plaques of
Alzheimer's disease (AD), little is known about the molecular changes and cellular …

The pathogenesis of Alzheimer disease (AD) involves the complex interaction between
genetic and environmental factors affecting multiple cellular pathways. Recent advances in …

Although the genetic causes for several rare, familial forms of Alzheimer's disease (AD) have
been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a …

The repeated failures of amyloid-targeting therapies have challenged our narrow
understanding of Alzheimer's disease (AD) pathogenesis and inspired wide-ranging …

Genome-wide association studies have identified many loci associated with Alzheimer's
dementia. However, these variants only explain part of the heritability of Alzheimer's disease …

Previous studies have evaluated gene expression in Alzheimer's disease (AD) brains to
identify mechanistic processes, but have been limited by the size of the datasets studied …

The human brain is composed of functional networks that have a modular topology, where
brain regions are organized into communities that form internally dense (segregated) and …

Because mouse models play a crucial role in biomedical research related to the human
nervous system, understanding the similarities and differences between mouse and human …

Interactome maps are valuable resources to elucidate protein function and disease
mechanisms. Here, we report on an interactome map that focuses on neurodegenerative …