[HTML][HTML] Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases
Introduction Comparative transcriptome analyses in Alzheimer's disease (AD) and other
neurodegenerative proteinopathies can uncover both shared and distinct disease pathways …
neurodegenerative proteinopathies can uncover both shared and distinct disease pathways …
Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease
Continuing efforts from large international consortia have made genome-wide epigenomic
and transcriptomic annotation data publicly available for a variety of cell and tissue types …
and transcriptomic annotation data publicly available for a variety of cell and tissue types …
Towards understanding brain-gut-microbiome connections in Alzheimer's disease
R Xu, QQ Wang - BMC systems biology, 2016 - Springer
Background Alzheimer's disease (AD) is complex, with genetic, epigenetic, and
environmental factors contributing to disease susceptibility and progression. While …
environmental factors contributing to disease susceptibility and progression. While …
[HTML][HTML] Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum
DT Jones, J Graff-Radford, VJ Lowe, HJ Wiste… - Cortex, 2017 - Elsevier
Functionally related brain regions are selectively vulnerable to Alzheimer's disease
pathophysiology. However, molecular markers of this pathophysiology (ie, beta-amyloid and …
pathophysiology. However, molecular markers of this pathophysiology (ie, beta-amyloid and …
Transcriptomics profiling of Alzheimer's disease reveal neurovascular defects, altered amyloid-β homeostasis, and deregulated expression of long noncoding RNAs
M Magistri, D Velmeshev… - Journal of …, 2015 - content.iospress.com
The underlying genetic variations of late-onset Alzheimer's disease (LOAD) cases remain
largely unknown. A combination of genetic variations with variable penetrance and lifetime …
largely unknown. A combination of genetic variations with variable penetrance and lifetime …
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
V Swarup, FI Hinz, JE Rexach, K Noguchi… - Nature medicine, 2019 - nature.com
Identifying the mechanisms through which genetic risk causes dementia is an imperative for
new therapeutic development. Here, we apply a multistage, systems biology approach to …
new therapeutic development. Here, we apply a multistage, systems biology approach to …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
Dissecting complex and multifactorial nature of Alzheimer's disease pathogenesis: a clinical, genomic, and systems biology perspective
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease
Recent advances toward the characterization of Alzheimer's disease (AD) have permitted
the identification of a dozen of genetic risk factors, although many more remain …
the identification of a dozen of genetic risk factors, although many more remain …
Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging
Alzheimer's disease (AD) is a complex neurodegenerative disorder that diverges from the
process of normal brain aging by unknown mechanisms. We analyzed the global structure of …
process of normal brain aging by unknown mechanisms. We analyzed the global structure of …