Diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) arise from
complex interactions of genetic and environmental factors, with genetic variants regulating …

Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …

Significant progress has been made uncovering functional brain networks, yet little is known
about the corresponding structural covariance networks. The default network's functional …

The hallmark clinical symptom of early Alzheimer's disease (AD) is episodic memory
impairment. Recent functional imaging studies suggest that memory function is subserved …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …

Alzheimer's disease (AD) is a neurodegenerative disorder that by affecting specific brain cell
types and regions cause severe pathological and functional changes in memory neural …

Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

Background Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia.
Recent large genome-wide association studies (GWAS) identified the first strongly …