m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2
W Wang, Y He, LL Zhai, LJ Chen, LC Yao, L Wu… - Epigenetics, 2022 - Taylor & Francis
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …
RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2-dependent …
Z Tan, S Shi, J Xu, X Liu, Y Lei, B Zhang, J Hua… - Oncogene, 2022 - nature.com
Abstract RNA N6-methyladenosine (m6A) is an emerging regulator of mRNA modifications
and represents a novel player in tumorigenesis. Although it has functional significance in …
and represents a novel player in tumorigenesis. Although it has functional significance in …
[HTML][HTML] m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation
J Li, L Zhu, Y Shi, J Liu, L Lin… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) acts as the most common mRNA modification in
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …
The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels
K Zhu, Y Li, Y Xu - Life Sciences, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A) is the most frequent posttranscriptional
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
N6‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion
W Wang, Y He, L Wu, LL Zhai, LJ Chen… - Cancer …, 2023 - Wiley Online Library
Pancreatic cancer (PC) is a deadly disease, and its post‐transcriptional gene regulation
mechanism remains unclear. The abundant extracellular matrix (ECM) in PC plays an …
mechanism remains unclear. The abundant extracellular matrix (ECM) in PC plays an …
FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
Y Niu, Z Lin, A Wan, H Chen, H Liang, L Sun, Y Wang… - Molecular cancer, 2019 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most pervasive
modification in mRNA, and has been considered as a new layer of epigenetic regulation on …
modification in mRNA, and has been considered as a new layer of epigenetic regulation on …
Fat mass and obesity-associated protein promotes the tumorigenesis and development of liver cancer
Z Ye, S Wang, W Chen, X Zhang, J Chen… - Oncology …, 2020 - spandidos-publications.com
Liver cancer is the fourth leading cause of cancer‑associated mortality worldwide. Statistics
indicate that the incidence of liver cancer has been increasing and that its prognosis …
indicate that the incidence of liver cancer has been increasing and that its prognosis …
FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner
J Huang, W Sun, Z Wang, C Lv, T Zhang… - Journal of Experimental …, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most common chemical
modification in mammalian mRNAs, and it plays important roles by regulating several …
modification in mammalian mRNAs, and it plays important roles by regulating several …
FTO-stabilized miR-139–5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway
B Azhati, A Reheman, D Dilixiati, M Rexiati - Archives of Biochemistry and …, 2023 - Elsevier
As one of the most important demethylases for RNA N6-methyladenosine (m6A)
modifications, fat mass and obesity-associated protein (FTO) plays anti-cancer role during …
modifications, fat mass and obesity-associated protein (FTO) plays anti-cancer role during …