The intestinal epithelial apical junctional complex, which includes tight and adherens
junctions, contributes to the intestinal barrier function via their role in regulating paracellular …

Intestinal barrier function is required for the maintenance of mucosal homeostasis. Barrier
dysfunction is thought to promote progression of both intestinal and systemic diseases. In …

Dynamic regulation of paracellular permeability is essential for physiological epithelial
function, while dysregulated permeability is common in disease. The recent elucidation of …

The barrier function of the intestine is essential for maintaining the normal homeostasis of
the gut and mucosal immune system. Abnormalities in intestinal barrier function expressed …

Background & Aims: Maintenance of the mucosal barrier is a critical function of intestinal
epithelia. Myosin regulatory light chain (MLC) phosphorylation is a common intermediate in …

Activation of Na+-nutrient cotransport leads to increased tight junction permeability in
intestinal absorptive (villus) enterocytes. This regulation requires myosin II regulatory light …

The patients with Crohn's disease (CD) have a 'leaky gut'manifested by an increase in
intestinal epithelial tight junction (TJ) permeability. Tumour necrosis factor‐α (TNF‐α) is a …

Background & Aims: Smooth muscle is essential for maintaining homeostasis for many body
functions and provides adaptive responses to stresses imposed by pathologic disorders …

Background The myosin light chain kinase (MLCK) pathway controls intestinal epithelial
barrier permeability by regulating the tight junction. 1, 25-dihydroxyvitamin D (1, 25 (OH) …

Numerous intestinal diseases are characterized by immune cell activation and compromised
epithelial barrier function. We have shown that cytokine treatment of epithelial monolayers …