Autophagy has long been thought to be an essential but unselective bulk degradation
pathway. However, increasing evidence suggests selective autophagosomal turnover of a …

Selective autophagy contributes to intracellular homeostasis by mediating the degradation
of cytoplasmic material such as aggregated proteins, damaged or over-abundant …

Macroautophagy, initially described as a non-selective nutrient recycling process, is
essential for the removal of multiple cellular components. In the past three decades …

Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis
by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign …

Autophagy is a process tightly regulated by various autophagy-related proteins. It is
generally classified into non-selective and selective autophagy. Whereas non-selective …

Selective autophagy is a quality control pathway through which cellular components are
sequestered into double-membrane vesicles and delivered to specific intracellular …

While the molecular mechanism of autophagy is well studied, the cargoes delivered by
autophagy remain incompletely characterized. To examine the selectivity of autophagy …

Cellular homeostasis requires the swift and specific removal of damaged material. Selective
autophagy represents a major pathway for the degradation of such cargo material. This is …

Autophagy is a catabolic 'self-eating'pathway that is emerging as a crucial integration point
in cell physiology. With its own set of genes, the autophagy pathway communicates with …

Selective autophagy is critical for regulating cellular homeostasis by mediating lysosomal
turnover of a wide variety of substrates including proteins, aggregates, organelles, and …