Identification of functional, noncoding elements that regulate transcription in the context of
complex genomes is a major goal of modern biology. Localization of functionality to specific …

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation
in all organisms. Genetic variation in regulatory regions has been connected with diseases …

Expression of eukaryotic genes with complex spatial‐temporal regulation during
development requires finer regulation than that of genes with simpler expression patterns …

Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

We developed a quantitative methodology, digital analysis of chromatin structure (DACS),
for high-throughput, automated mapping of DNase I-hypersensitive sites and associated cis …

DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA,,,–and contain
genetic variations associated with diseases and phenotypic traits,–. We created high …

DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned
the discovery of all classes of cis-regulatory elements including enhancers, promoters …

Localized accessibility of critical DNA sequences to the regulatory machinery is a key
requirement for regulation of human genes. Here we describe a high-resolution, genome …

The ENCODE Project has generated a wealth of experimental information mapping diverse
chromatin properties in several human cell lines. Although each such data track is …