Aprotic solvents are usually preferred for the SN2 reactions, because nucleophilicity and
hence SN2 reactivity are severely retarded by the influence of the partial positive charge of …

Although protic solvents are generally not preferred for nucleophilic displacement reactions
because of their partial positive charge and hydrogen-bonding capacity that solvate the …

Due to the tremendous interest in carbon–fluorine bond-forming reactions, research efforts
in this area have been dedicated to the development of facile processes to synthesize small …

An efficient and direct monofluoromethylation of O-, S-, N-, and P-nucleophiles with PhSO
(NTs) CH2F 1 has been developed. In contrast to the previously known detrimental effect of …

This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

A novel [18F] NF reagent and two novel radiochemical transformations have been
developed:[18F] NFSi has been prepared from sodium dibenzenesulfonimide and reacted in …

(E)-and (Z)-Fluorovinyl sulfones (II) form (fluorovinyl) stannanes (III) on treatment with two
equivalents of tributyltin hydride and a catalytic amount of AIBN; the free radical catalyzed …

A copper-mediated nucleophilic radiofluorination of aryl-and vinylstannanes with [18F] KF is
described. This method is fast, uses commercially available reagents, and is compatible with …

This article focuses on the development of practical approaches to the in situ generation of
anhydrous fluoride salts for applications in nucleophilic aromatic substitution (SNAr) …

The generally favorable pharmaceutical properties of many low fluorinated compounds and
18F-labeled radiopharmaceuticals for positron emission tomography (PET) molecular …