Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the
architecture of the transcriptional regulatory circuitry responsible for cell determination …

There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using …

Transcriptional regulation is one of the most fundamental processes in biology, governing
the morphology, function, and behavior of cells and thus the survival of organisms. The …

The transcription factors OCT4, SOX2, and NANOG have essential roles in early
development and are required for the propagation of undifferentiated embryonic stem (ES) …

We analyze new and existing expression and transcription factor-binding data to
characterize gene regulatory relations in mouse ES cells (ESC). In addition to confirming the …

The expression of the transcription factors Oct4, Sox2, and Nanog is commonly associated
with pluripotency of mouse embryonic stem (ES) cells. However, recent observations …

Stem cell differentiation has been viewed as coming from transitions between attractors on
an epigenetic landscape that governs the dynamics of a regulatory network involving many …

Background Genome-wide approaches have begun to reveal the transcriptional networks
responsible for pluripotency in embryonic stem (ES) cells. Chromatin Immunoprecipitation …

Background Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog
as parts of a self-regulating network which is responsible for maintaining embryonic stem …

Sox2 is a transcription factor required for the maintenance of pluripotency. It also plays an
essential role in different types of multipotent stem cells, raising the possibility that Sox2 …