Experimental evidence supports an intricate association between inflammation and
mitochondrial dysfunction as main contributors of neurological diseases. Inflammatory …

Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals
triggering the release of mtDNA from mitochondria remain enigmatic. Here, we show that …

BACKGROUND Evolution generally trundles along by selecting for mutations or by
leveraging the new realms generated from chromosomal amplifications and the transfer of …

During tissue injury events, the innate immune system responds immediately to alarms sent
from the injured cells, and the adaptive immune system subsequently joins in the …

Mitochondria, cellular powerhouses of eukaryotes, are known to act as central hubs for
multiple signal transductions. Recent research reveals that mitochondria are involved in …

Innate immune response is one of our primary defenses against pathogens infection,
although, if dysregulated, it represents the leading cause of chronic tissue inflammation. This …

Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Understanding why the response to infection varies between individuals remains one of the
major challenges in immunology and infection biology. A substantial proportion of this …

Viruses manipulate cellular machinery and functions to subvert intracellular environment
conducive for viral proliferation. They strategically alter functions of the multitasking …

In the last decade, there has been an increased appreciation for mitochondria as central
hubs in diverse processes, such as cellular energy, immunity, and signal transduction. As …