A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation
To characterize the genetic basis of facial features in Latin Americans, we performed a
genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark …
genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark …
Novel genetic loci affecting facial shape variation in humans
The human face represents a combined set of highly heritable phenotypes, but knowledge
on its genetic architecture remains limited, despite the relevance for various fields. A series …
on its genetic architecture remains limited, despite the relevance for various fields. A series …
Genome-wide mapping of global-to-local genetic effects on human facial shape
Genome-wide association scans of complex multipartite traits like the human face typically
use preselected phenotypic measures. Here we report a data-driven approach to …
use preselected phenotypic measures. Here we report a data-driven approach to …
Genetic variants underlying differences in facial morphology in East Asian and European populations
Facial morphology—a conspicuous feature of human appearance—is highly heritable.
Previous studies on the genetic basis of facial morphology were performed mainly in …
Previous studies on the genetic basis of facial morphology were performed mainly in …
A genome-wide association study identifies five loci influencing facial morphology in Europeans
Inter-individual variation in facial shape is one of the most noticeable phenotypes in
humans, and it is clearly under genetic regulation; however, almost nothing is known about …
humans, and it is clearly under genetic regulation; however, almost nothing is known about …
Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations
Facial morphology is highly variable, both within and among human populations, and a
sizable portion of this variation is attributable to genetics. Previous genome scans have …
sizable portion of this variation is attributable to genetics. Previous genome scans have …
Insights into the genetic architecture of the human face
The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …
remains challenging. Using a multivariate genome-wide association study meta-analysis of …
Decoding the human face: progress and challenges in understanding the genetics of craniofacial morphology
Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …
societal interactions, have fascinated scientists and artists alike. Here, we review our current …
Genome-wide association study reveals multiple loci influencing normal human facial morphology
JR Shaffer, E Orlova, MK Lee, EJ Leslie… - PLoS …, 2016 - journals.plos.org
Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet
little is known about how specific genetic variants relate to the phenotypic expression of …
little is known about how specific genetic variants relate to the phenotypic expression of …
Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape
JB Cole, M Manyama, E Kimwaga, J Mathayo… - PLoS …, 2016 - journals.plos.org
The human face is a complex assemblage of highly variable yet clearly heritable anatomic
structures that together make each of us unique, distinguishable, and recognizable …
structures that together make each of us unique, distinguishable, and recognizable …