Use-dependent movement therapies can lead to partial recovery of motor function after
neurological injury. We attempted to improve recovery by developing a neuroprosthetic …

Axonal regeneration and fiber regrowth is limited in the adult central nervous system, but
research over the last decades has revealed a high intrinsic capacity of brain and spinal …

The state of areflexia and muscle weakness that immediately follows a spinal cord injury
(SCI) is gradually replaced by the recovery of neuronal and network excitability, leading to …

The mammalian lumbar spinal cord has the capability to generate locomotor activity in the
absence of input from the brain. Previously, we reported that transcutaneous electrical …

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models
and humans with spinal cord injury. With common neuromodulation devices, electrical …

One consequence of central nervous system injury or disease is the impairment of neural
control of movement, resulting in spasticity and paralysis. To enhance recovery, restorative …

We review some basic and highly relevant concepts in the effort to develop improved
rehabilitative interventions for subjects with spinal cord injury (SCI). Interventions that are …

Body-weight supported locomotor training (BWST) promotes recovery of load-bearing
stepping in lower mammals, but its efficacy in individuals with a spinal cord injury (SCI) is …

Background Traumatic spinal cord injury (SCI) disrupts signaling pathways between the
brain and spinal networks below the level of injury. In cases of severe SCI, permanent loss …

The purpose of this study was to examine if a delay in rehabilitative motor training after
spinal cord injury affects functional motor recovery. We studied a skilled motor task in which …