Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives

G Campiani, A Ramunno, G Maga… - Current …, 2002 - ingentaconnect.com
Along with nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),
nonnucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive and …

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005–2010)

P Zhan, X Liu - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) form the backbone of
antiretroviral treatment for many HIV-infected individuals. The unique antiviral activity, high …

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011–2014)

X Li, L Zhang, Y Tian, Y Song, P Zhan… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: There is a continuous need for next-generation non-nucleoside RT inhibitors
(NNRTIs) with different resistance profiles, improved safety, excellent tolerability, and …

Non-nucleoside reverse transcriptase inhibitors: perspectives on novel therapeutic compounds and strategies for the treatment of HIV infection

RW Buckheit - Expert Opinion on Investigational Drugs, 2001 - Taylor & Francis
At present, the nucleoside reverse transcriptase (RT) inhibitors and protease inhibitors (PI)
have dominated the therapeutic options for the treatment of human immunodeficiency virus …

The journey of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) from lab to clinic

V Namasivayam, M Vanangamudi… - Journal of medicinal …, 2018 - ACS Publications
Human immunodeficiency virus (HIV) infection is now pandemic. Targeting HIV-1 reverse
transcriptase (HIV-1 RT) has been considered as one of the most successful targets for the …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989 …

MP de Béthune - Antiviral research, 2010 - Elsevier
It is almost 20 years since NNRTIs were identified as a new class of antiretroviral drugs for
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …

Development of non-nucleoside reverse transcriptase inhibitors for anti-HIV therapy

C Sahlberg, XX Zhou - Anti-Infective Agents in Medicinal …, 2008 - ingentaconnect.com
The NNRTIs play an important role in the present therapy against HIV/AIDS. This review
discusses the basic principles in the development of NNRTIs for HIV therapy. It also …

Twenty years of HIV-1 non-nucleoside reverse transcriptase inhibitors: time to reevaluate their toxicity

A Blas-Garcia, JV Esplugues… - Current medicinal …, 2011 - ingentaconnect.com
Twenty years of effective clinical application have consolidated non-nucleoside reverse
transcriptase inhibitors (NNRTI) as essential components of the Highly Active Antiretroviral …

Recent discoveries in HIV-1 reverse transcriptase inhibitors

SX Gu, YY Zhu, C Wang, HF Wang, GY Liu… - Current Opinion in …, 2020 - Elsevier
HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active
antiretroviral therapy (HAART), which has achieved great success in controlling AIDS …

Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom

OS Pedersen, EB Pedersen - Antiviral Chemistry and …, 1999 - journals.sagepub.com
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the
treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside …