The repair of bone defects poses a great challenge for reconstructive surgeons. Although
the development of tißsue engineering has exhibited promise in replacing damaged bone …

The repair of bone defects remains a major clinical challenge because none available
reconstruction methods and biomaterials have been proved completely satisfactory. As a …

The aim of this project was to construct vascularized tissue‐engineered living bone with an
autologous vascular network by means of a rabbit bioreactor in vivo. The key components of …

This article describes the prefabrication of a vascularized bone graft composed of
autologous particulate cancellous bone and marrow (PCBM), a vessel bundle, and a …

It is a common treatment strategy in the clinic to transplant a vascularized bone flap for a
large bone defect. But it is difficult for peripheral blood vessels to grow into the central region …

We aimed to introduce an in vivo bioreactor‐vascular pedicle threaded through the central
portion of a scaffold in which a vascularized bone graft was prefabricated using adenoviral …

Background Neovascularization is critical for bone regeneration. Numerous studies have
explored prevascularization preimplant strategies, ranging from calcium phosphate cement …

Although vascularized tissue-engineered bone grafts (TEBG) have been generated
ectopically in several studies, the use of prevascularized TEBG for segmental bone defect …

Although small animal model (rabbit) showed successful bone defect repair using
prevascularized tissue-engineered bone grafts (TEBG), large animal (rhesus monkey) …

To date, the recovery of large bone defects is a major clinical challenge despite the
availability of numerous therapeutic procedures including tissue engineering. Although …