Addition of a macrolide to a β-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal …

JA Martínez, JP Horcajada, M Almela… - Clinical Infectious …, 2003 - academic.oup.com
To assess the association between inclusion of a macrolide in a β-lactam—based empirical
antibiotic regimen and mortality among patients with bacteremic pneumococcal pneumonia …

Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a beta-lactam agent alone

E Garcia Vazquez, J Mensa, JA Martinez… - European journal of …, 2005 - Springer
A cohort of 1,391 patients with community-acquired pneumonia of unknown etiology,
atypical pneumonia, Legionella pneumophila pneumonia, viral pneumonia, or …

Impact of initial antibiotic choice on mortality from pneumococcal pneumonia

J Aspa, O Rajas, FR de Castro… - European …, 2006 - Eur Respiratory Soc
To determine the impact of initial antimicrobial choice on 30-day mortality rate in patients
with community-acquired pneumonia due to Streptococcus pneumoniae (CAP-SP), a …

Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia

GW Waterer, GW Somes… - Archives of internal …, 2001 - jamanetwork.com
Background Although monotherapy for pneumococcal pneumonia is standard, a survival
benefit of combination β-lactam and macrolide therapy has been suggested. Hypothesis …

Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones

ML Metersky, A Ma, PM Houck, DW Bratzler - Chest, 2007 - Elsevier
Background: The questions of whether the use of antibiotics that are active against atypical
organisms is beneficial in the treatment of community-acquired pneumonia and of the …

Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia

LM Baddour, VL Yu, KP Klugman… - American journal of …, 2004 - atsjournals.org
Retrospective studies have suggested that combination antibiotic therapy for severe
bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a …

Empiric antibiotic therapy and mortality among Medicare pneumonia inpatients in 10 western states: 1993, 1995, and 1997

PM Houck, RF MacLehose, MS Niederman, JK Lowery - Chest, 2001 - Elsevier
Study objectives: To examine the association of empiric inpatient antibiotic treatment of
community-acquired pneumonia (CAP) with mortality, and whether this association varies …

Clinical Characteristics at Initial Presentation and Impact of Dual Therapy on the Outcome of Bacteremic Streptococcus pneumoniae Pneumonia in Adults

K Weiss, DE Low, L Cortes, A Beaupre… - Canadian respiratory …, 2004 - Wiley Online Library
BACKGROUND: Approximately 10% of patients hospitalized with community‐acquired
pneumonia (CAP) are bacteremic. Bacteremic Streptococcus pneumoniae pneumonia …

Prospective observational study of bacteremic pneumococcal pneumonia: effect of discordant therapy on mortality

M Lujan, M Gallego, D Fontanals, D Mariscal… - Critical care …, 2004 - journals.lww.com
Prospective observational study of bacteremic pneumococcal p... : Critical Care Medicine
Prospective observational study of bacteremic pneumococcal pneumonia: Effect of discordant …

Antibiotic therapy for adults hospitalized with community-acquired pneumonia: a systematic review

JS Lee, DL Giesler, WF Gellad, MJ Fine - Jama, 2016 - jamanetwork.com
Importance Antibiotic therapy is the cornerstone of medical management for community-
acquired pneumonia. Objective To assess the associations between 3 key aspects of …