Current cancer therapies target a limited set of tumor features, rather than considering the
tumor as a whole. Systems biology aims to reveal therapeutic targets associated with a …

The development of cost-effective technologies able to comprehensively assess DNA, RNA,
protein, and metabolites in patient tumors has fueled efforts to tailor medical care. Indeed …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …

Cancer is a complex and heterogeneous disease, demonstrating variations with respect to
tumor types and between individual tumors. This heterogeneity has complicated the search …

The recent wide-spread adoption of single-cell profiling technologies has revealed that
individual cancers are not homogenous collections of deregulated cells, but instead …

Simple Summary Omics technologies and targeted drugs are revolutionizing the clinical
oncology landscape, portending the promise of precision oncology. However, our abilities to …

Cancer is a highly complex disease that is often characterized by vast changes in the
genetic and epigenetic landscape. Those changes result in altered protein expression levels …

Cancer systems biology aims to understand cancer as an integrated system of genes,
proteins, networks, and interactions rather than an entity of isolated molecular and cellular …

An important challenge facing the field is how better to translate in vitro discoveries to the
clinic. Computational systems biology approaches that use omic data to predict biology …