Skeletal muscle regeneration results from the activation and differentiation of myogenic stem
cells, called satellite cells, located beneath the basal lamina of the muscle fibers …

Ageing is characterised by progressive deterioration of physiological systems and the loss of
skeletal muscle mass is one of the most recognisable, leading to muscle weakness and …

Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a
dynamic inflammatory microenvironment consisting of a complex network formed by the …

Muscle injury induces a classical inflammatory response in which cells of the innate immune
system rapidly invade the tissue. Macrophages are prominently involved in this response …

Skeletal muscle regeneration is a complex process, which is not yet completely understood.
Satellite cells, the skeletal muscle stem cells, become activated after trauma, proliferate, and …

A distinct population of Foxp3+ CD4+ regulatory T (Treg) cells promotes repair of acutely or
chronically injured skeletal muscle. The accumulation of these cells depends critically on …

Long recognized to be potent suppressors of immune responses, Foxp3+ CD4+ regulatory T
(Treg) cells are being rediscovered as regulators of nonimmunological processes. We …

Normal repair of skeletal muscle requires local expansion of a special population of Foxp3+
CD4+ regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of …

We examined the hypothesis that regulatory T cells (Tregs) modulate muscle injury and
inflammation in the mdx mouse model of Duchenne muscular dystrophy (DMD). Although …

Skeletal muscle is prone to damage from a range of stimuli, and initiates a robust repair
process that requires the participation of immune cells. Among the more well characterized …