[PDF][PDF] Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia

AC Need, JP McEvoy, M Gennarelli, EL Heinzen… - The American Journal of …, 2012 - cell.com
Schizophrenia is a severe psychiatric disorder with strong heritability and marked
heterogeneity in symptoms, course, and treatment response. There is strong interest in …

Genome sequencing broadens the range of contributing variants with clinical implications in schizophrenia

BA Mojarad, Y Yin, R Manshaei, I Backstrom… - Translational …, 2021 - nature.com
The range of genetic variation with potential clinical implications in schizophrenia, beyond
rare copy number variants (CNVs), remains uncertain. We therefore analyzed genome …

Genetics of schizophrenia: ready to translate?

C Foley, A Corvin, S Nakagome - Current psychiatry reports, 2017 - Springer
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …

Genome‐wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

TB Bigdeli, S Ripke, SA Bacanu, SH Lee… - American Journal of …, 2016 - Wiley Online Library
Genome‐wide association studies (GWAS) of schizophrenia have yielded more than 100
common susceptibility variants, and strongly support a substantial polygenic contribution of …

Genome-wide association studies of schizophrenia: does bigger lead to better results?

SE Bergen, TL Petryshen - Current opinion in psychiatry, 2012 - journals.lww.com
Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

AF Pardiñas, P Holmans, AJ Pocklington… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia

MJ Owen, N Craddock… - Archives of general …, 2010 - jamanetwork.com
This article reviews recent genome-wide association studies (GWAS) of schizophrenia and
considers future research directions. Until recently, genome-wide scans for dis-ease risk …

Exome arrays capture polygenic rare variant contributions to schizophrenia

AL Richards, G Leonenko, JT Walters… - Human molecular …, 2016 - academic.oup.com
Schizophrenia is a highly heritable disorder. Genome-wide association studies based
largely on common alleles have identified over 100 schizophrenia risk loci, but it is also …

Genome‐wide association study of schizophrenia in Ashkenazi Jews

FS Goes, J McGrath, D Avramopoulos… - American Journal of …, 2015 - Wiley Online Library
Schizophrenia is a common, clinically heterogeneous disorder associated with lifelong
morbidity and early mortality. Several genetic variants associated with schizophrenia have …