OBJECTIVE: Alterations of wall shear stress can predispose the endothelium to the
development of atherosclerotic plaques. Ample evidence indicates that arginase expression …

AIMS: Wall shear stress differentially regulates the arginase pathway in carotid arteries
perfused ex vivo. Specific patterns of wall shear stress can locally determine atherosclerotic …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Background Arterial stiffness (AS) is an independent risk factor for cardiovascular
morbidity/mortality. Smooth muscle cell (SMC) proliferation and increased collagen …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Hypoxia-induced arginase elevation plays an essential role in several vascular diseases but
influence of arginase on hypoxia-mediated angiogenesis is completely unknown. In this …

There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

Aims The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque
stabilization in unruptured atherosclerotic plaque and explore its mechanism. Methods and …

Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells
(VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …