Background Gastric cancer (GC), an aggressive malignant tumor of the alimentary tract, is a
leading cause of cancer-related death. Circadian rhythm exhibits a 24-hour variation in …

There is accumulating evidence for a link between circadian clock disruption and cancer
progression. In this study, the circadian clock was investigated in cervical and esophageal …

Background Per1, Per2, Per3, Cry1, Cry2, Bmal1, Npas2 and CLOCK genes are the eight
core circadian clock genes. Low expression of these circadian clock genes plays an …

Circadian rhythm describes the 24-h oscillation in physiology and behavior of living
organisms and presents a timing controller for life activity. Studies in recent years have …

Introduction The circadian rhythm is responsible for physiologic homeostasis, behavior, and
components of multiple metabolic processes. Disruption of the circadian rhythm is …

Circadian rhythms are fundamental biological systems in most organisms. Epidemiological
and animal studies have demonstrated that disruption of circadian rhythms is linked to tumor …

The circadian timing system controls about 40% of the transcriptome and is important in the
regulation of a wide variety of biological processes including metabolic and proliferative …

The clock gene machinery controls cellular metabolism, proliferation, and key functions,
such as DNA damage recognition and repair. Dysfunction of the circadian clock is involved …

Background Recent studies have shown that disruption of circadian rhythms is one of the
tumor promoting factors which contribute to mammalian cancer development and …

Background: Stomach adenocarcinoma (STAD) is one of the most prevalent malignances
and ranks fifth in incidence and third in cancer-related death among all malignances. The …