[HTML][HTML] Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants

J Ter Meulen, EN Van Den Brink, LLM Poon… - PLoS …, 2006 - journals.plos.org
Background Experimental animal data show that protection against severe acute respiratory
syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is …

[HTML][HTML] Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using …

M Coughlin, G Lou, O Martinez, SK Masterman… - Virology, 2007 - Elsevier
Passive therapy with neutralizing human monoclonal antibodies (mAbs) could be an
effective therapy against severe acute respiratory syndrome coronavirus (SARS-CoV) …

[HTML][HTML] Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing

HA Elshabrawy, MM Coughlin, SC Baker… - PloS one, 2012 - journals.plos.org
Immune sera from convalescent patients have been shown to be effective in the treatment of
patients infected with Severe Acute Respiratory Syndrome Virus (SARS-CoV) making …

Neutralizing epitopes of the SARS-CoV S-protein cluster independent of repertoire, antigen structure or mAb technology

JD Berry, K Hay, JM Rini, M Yu, L Wang, FA Plummer… - MAbs, 2010 - Taylor & Francis
Neutralizing antibody responses to the surface glycoproteins of enveloped viruses play an
important role in immunity. Many of these glycoproteins, including the severe acute …

Development and characterization of a severe acute respiratory syndrome—associated coronavirus—neutralizing human monoclonal antibody that provides effective …

TC Greenough, GJ Babcock, A Roberts… - The Journal of …, 2005 - academic.oup.com
Background. Severe acute respiratory syndrome (SARS) remains a significant public health
concern after the epidemic in 2003. Human monoclonal antibodies (MAbs) that neutralize …

Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies

Z Zhu, S Chakraborti, Y He, A Roberts… - Proceedings of the …, 2007 - National Acad Sciences
The severe acute respiratory syndrome coronavirus (SARS-CoV) caused a worldwide
epidemic in late 2002/early 2003 and a second outbreak in the winter of 2003/2004 by an …

Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus

B Rockx, E Donaldson, M Frieman… - The Journal of …, 2010 - academic.oup.com
Background. Severe acute respiratory syndrome (SARS) emerged as a human disease in
2002. Detailed phylogenetic analysis and epidemiologic studies have suggested that the …

Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome …

B Rockx, D Corti, E Donaldson, T Sheahan… - Journal of …, 2008 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002, and detailed
phylogenetic and epidemiological analyses have suggested that it originated from animals …

Therapy with a severe acute respiratory syndrome–associated coronavirus–neutralizing human monoclonal antibody reduces disease severity and viral burden in …

A Roberts, WD Thomas, J Guarner… - The Journal of …, 2006 - academic.oup.com
Background Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for
the prevention of infection in patients after organ transplantation and for the treatment of …

Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential

MM Coughlin, BS Prabhakar - Reviews in medical virology, 2012 - Wiley Online Library
SUMMARY The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS‐
CoV) led to a rapid response not only to contain the outbreak but also to identify possible …