Carbonic anhydrase II (CAII) deficiency in humans is associated with a syndrome of renal
tubular acidosis, osteopetrosis, and cerebral calcification. A strain of mice of CAII deficiency …

Carbonic anhydrases are a group of isoenzymes that catalyze the reversible conversion of
carbon dioxide into bicarbonate. They participate in a constellation of physiological …

Osteopetrosis is a rare skeletal condition characterized by skeletal sclerosis caused by
aberrant osteoclast-mediated bone resorption. Three clinically distinct forms of osteopetrosis …

Major contributions to and confirmations of osteoclast biology have been made by
experimental investigations of the osteopetrotic mutations in mammals. Congenital …

Objective To describe the long term clinical, biochemical and radiological features of 35
Saudi Arabian children with carbonic anhydrase II deficiency syndrome who have been …

Osteoclasts are multinucleated bone-resorbing cells that use multiple pH regulation
mechanisms to create an acidic pH in the resorption lacuna. Carbonic anhydrase II and …

Excessive chloride secretion in sweat (hyperchlorhidrosis), leading to a positive sweat test,
is most commonly indicative of cystic fibrosis yet is found also in conjunction with various …

Purpose: Four mitochondrial metabolic liver enzymes require bicarbonate, which is provided
by the carbonic anhydrase isoforms VA (CAVA) and VB (CAVB). Defective hepatic …

Carbonic anhydrase XIV: Luminal expression suggests key role in renal acidification.
Background Carbonic anhydrase (CA) plays a fundamental role in regulation of systemic …

Chronic metabolic acidosis (CMA) in the rabbit upregulates carbonic anhydrase (CA) IV in
the proximal convoluted tubule (PCT). This study was designed to assess CA IV expression …