Melanin synthesis is an oxygen‐dependent process that acts as a potential source of
reactive oxygen species (ROS) inside pigment‐forming cells. The synthesis of the lighter …

Dysplastic naevi (DN) are a known risk factor for malignant melanoma. Their occurrence is
closely connected with the degree of skin pigmentation. People with a light complexion are …

Melanins have been associated with the development of melanoma and its resistance to
photodynamic therapy (PDT). Singlet molecular oxygen (1O2), which is produced by …

Exposure of cultured human melanocytes to ultraviolet radiation (UV) results in DNA
damage. In melanoma, UV‐signature mutations resulting from unrepaired photoproducts are …

Although the ability of UV irradiation to induce pigmentation in vivo and in vitro is well
documented, the intracellular signals that trigger this response are poorly understood. We …

Melanin is both photosensitizer and photoprotector. Skin cancer rates decrease with
increasing constitutive pigmentation, yet the pigment has been shown to be photoreactive …

Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes
within melanocytes, the function of which is to protect skin against harmful effects of UV …

UV‐induced DNA damage can lead to melanoma, the most dangerous form of skin cancer.
Understanding the mechanisms employed by melanocytes to protect against UV is therefore …

The human melanocyte is continuously exposed to intrinsic and extrinsic sources of reactive
biochemical species, but is finely tuned via the intrinsic anti‐oxidant and radical properties of …

The question of whether melanins are photoprotecting and/or photosensitizing in human
skin cells continues to be debated. To evaluate the role of melanin upon UVA irradiation …