Background Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …

The G protein-coupled apelin receptor regulates important processes of the cardiovascular
homeostasis, including cardiac development, cardiac contractility, and vascular tone. Most …

Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …

Apelin interacts with the APJ receptor to enhance inotropy. In heart failure, apelin-APJ
coupling may provide a means of enhancing myocardial function. The alterations in apelin …

Objective: The endogenous peptide apelin is differentially regulated in cardiovascular
disease but the nature of its role in cardiac function remains unclear. Methods: We …

Background—Apelin is among the most potent stimulators of cardiac contractility known.
However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) …

Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor,
APJ. This novel peptidic signalling pathway is widely represented in the heart and …

The orphan receptor APJ and its recently identified endogenous ligand, apelin, exhibit high
levels of mRNA expression in the heart. However, the functional importance of apelin in the …

Apelin increases coronary blood flow, cardiac contractility, and cardiac output. Based on
these favorable hemodynamic effects, apelin and apelin-like analogs are being developed …

Apelin acts as the endogenous ligand of G protein coupled receptors APJ. The apelin/APJ
system is responsible for the occurrence and development of cardiovascular diseases. In …