Structural basis of a shared antibody response to SARS-CoV-2

M Yuan, H Liu, NC Wu, CCD Lee, X Zhu, F Zhao… - Science, 2020 - science.org
Molecular understanding of neutralizing antibody responses to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) could accelerate vaccine design and drug …

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

M Yuan, NC Wu, X Zhu, CCD Lee, RTY So, H Lv… - Science, 2020 - science.org
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently …

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

M Yuan, D Huang, CCD Lee, NC Wu, AM Jackson… - Science, 2021 - science.org
Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B. 1.1. 529

T Zhou, L Wang, J Misasi, A Pegu, Y Zhang, DR Harris… - Science, 2022 - science.org
The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.
1.1. 529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent …

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

PJM Brouwer, TG Caniels, K van der Straten… - Science, 2020 - science.org
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
had a large impact on global health, travel, and economy. Therefore, preventative and …

[HTML][HTML] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
The worldwide spread of COVID-19 highlights the need for an efficient approach to rapidly
develop therapeutics and prophylactics against SARS-CoV-2. The SARS-CoV-2 spike …

Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

KG Nabel, SA Clark, S Shankar, J Pan, LE Clark… - Science, 2021 - science.org
Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant …

Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

TJC Tan, M Yuan, K Kuzelka, GC Padron… - Nature …, 2021 - nature.com
Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been
extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike …

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

J Ge, R Wang, B Ju, Q Zhang, J Sun, P Chen… - Nature …, 2021 - nature.com
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the
development of effective therapeutics and vaccines. We recently isolated a large number of …

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

L Wang, T Zhou, Y Zhang, ES Yang, CA Schramm… - Science, 2021 - science.org
INTRODUCTION Worldwide appearance of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) variants of concern (VOCs) with increased transmissibility and resistance to …