Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19),
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …

The amount of cytokine-release defines different shades of Sars-Cov2 infection

S Bindoli, M Felicetti, P Sfriso… - … Biology and Medicine, 2020 - journals.sagepub.com
The recent outbreak of coronavirus disease (COVID 19), spreading from China all around
the world in early 2020, has led scientists to investigate the immuno-mediated mechanisms …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome
coronavirus 2 presents with a spectrum of clinical manifestations from asymptomatic or mild …

[HTML][HTML] Diverse immunological factors influencing pathogenesis in patients with COVID-19: a review on viral dissemination, immunotherapeutic options to counter …

AA Rabaan, SH Al-Ahmed, MA Garout, AM Al-Qaaneh… - Pathogens, 2021 - mdpi.com
The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …

Cytokine response in SARS-CoV-2 infection in the elderly

S Sherwani, MWA Khan - Journal of Inflammation Research, 2020 - Taylor & Francis
The last few months of 2019 witnessed the emergence, rise and rapid spread of a novel
coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

[PDF][PDF] Recent updates in the clinical trials of therapeutic monoclonal antibodies targeting cytokine storm for the management of COVID-19

S Patel, B Saxena, P Mehta - Heliyon, 2021 - cell.com
Clinical studies have identified a cytokine storm in the third stage of disease progression in
critical ill patients with coronavirus disease 2019 (COVID-19). Hence, effectively …

[HTML][HTML] A glimpse into the eye of the COVID-19 cytokine storm

K Kuppalli, AL Rasmussen - EBioMedicine, 2020 - thelancet.com
The pathogenesis of pandemic coronavirus disease-2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely depends heavily on …

[HTML][HTML] COVID-19: towards understanding of pathogenesis

W Cao, T Li - Cell research, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) is spreading rapidly. Although the
cause was quickly identified as a new coronavirus named SARS-CoV-2, our knowledge of …

COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
SARS-COV-2 infection represents the greatest pandemic of the world, counting daily
increasing number of subjects positive to the virus and, sadly, increasing number of deaths …