Multiomics studies investigating recurrent pregnancy loss: an effective tool for mechanism exploration

J Li, L Wang, J Ding, Y Cheng, L Diao, L Li… - Frontiers in …, 2022 - frontiersin.org
Patients with recurrent pregnancy loss (RPL) account for approximately 1%-5% of women
aiming to achieve childbirth. Although studies have shown that RPL is associated with …

Recurrent pregnancy loss: the key potential mechanisms

KH Baek, EJ Lee, YS Kim - Trends in molecular medicine, 2007 - cell.com
Recurrent pregnancy loss (RPL), which occurs in 0.5%–1% of total pregnancies, is usually
defined as three or more consecutive spontaneous abortions before 20 weeks of gestation …

Identification of novel biomarkers and immune infiltration features of recurrent pregnancy loss by machine learning

Y Luo, Y Zhou - Scientific reports, 2023 - nature.com
Recurrent pregnancy loss (RPL) is a complex reproductive disorder. The incompletely
understood pathophysiology of RPL makes early detection and exact treatment difficult. The …

Endometrial immune dysfunction in recurrent pregnancy loss

C Ticconi, A Pietropolli, N Di Simone… - International journal of …, 2019 - mdpi.com
Recurrent pregnancy loss (RPL) represents an unresolved problem for contemporary
gynecology and obstetrics. In fact, it is not only a relevant complication of pregnancy, but is …

Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA

C Wei, Y Wei, J Cheng, X Tan, Z Zhou, S Lin… - Frontiers in …, 2023 - frontiersin.org
Background Recurrent pregnancy loss defined as the occurrence of two or more pregnancy
losses before 20-24 weeks of gestation, is a prevalent and significant pathological condition …

Dysfunction of CCR1+ decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy loss

Y Sang, Y Li, L Xu, J Chen, D Li, M Du - Frontiers in Immunology, 2022 - frontiersin.org
Recurrent pregnancy loss (RPL) puzzles 1–3% of women of childbearing age worldwide.
Immunological factors account for more than 60% of cases of unexplained RPL (URPL); …

[HTML][HTML] Investigation and validation of molecular characteristics of endometrium in recurrent miscarriage and unexplained infertility from a transcriptomic perspective

Y Ran, J He, R Chen, Y Qin, Z Liu, Y Zhou… - … journal of medical …, 2022 - ncbi.nlm.nih.gov
Recurrent miscarriage (RM) and unexplained infertility (UI) are gordian knots in reproductive
medicine, which are troubling many patients, doctors, and researchers. Although these two …

The update immune-regulatory role of pro-and anti-inflammatory cytokines in recurrent pregnancy losses

X Yang, Y Tian, L Zheng, T Luu… - International journal of …, 2022 - mdpi.com
Recurrent pregnancy losses (RPL) is a common reproductive disorder with various
underlying etiologies. In recent years, rapid progress has been made in exploring the …

Single-cell immune landscape of human recurrent miscarriage

F Wang, W Jia, M Fan, X Shao, Z Li, Y Liu… - Genomics …, 2021 - academic.oup.com
Successful pregnancy in placental mammals substantially depends on the establishment of
maternal immune tolerance to the semi-allogenic fetus. Disorders in this process are tightly …

RNA sequencing of decidua reveals differentially expressed genes in recurrent pregnancy loss

Y Li, R Wang, M Wang, W Huang, C Liu, Z Fang… - Reproductive …, 2021 - Springer
Recurrent pregnancy loss (RPL) is affecting 3–5% of the women who are expecting to have
babies annually. However, the molecular changes of RPL patients have not been well …