Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

The development of cost-effective technologies able to comprehensively assess DNA, RNA,
protein, and metabolites in patient tumors has fueled efforts to tailor medical care. Indeed …

Abstract The AACR-NCI Conference “Systems Biology: Confronting the Complexity of
Cancer” took place from February 27 to March 2, 2011, in San Diego, CA. Several themes …

Current and emerging biomedical science efforts are driven by determining how to improve
clinical outcomes for patients, but the roadmap to achieve this goal has been controversial …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

A tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments
often target one clone of a tumor. Although the drug kills that clone, other clones overtake it …

Cancer research has focused on the identification of molecular differences between
cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules …

An important challenge facing the field is how better to translate in vitro discoveries to the
clinic. Computational systems biology approaches that use omic data to predict biology …

Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …