Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy

R Devillier, AS Chrétien, T Pagliardini… - Journal of Leucocyte …, 2021 - academic.oup.com
NK cells are innate immune cells with inherent capabilities in both recognizing and killing
cancer cells. NK cell phenotypes and functional alterations are being described with …

Plasticity of NK cells in Cancer

D Corvino, A Kumar, T Bald - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer (NK) cells are crucial to various facets of human immunity and function through
direct cytotoxicity or via orchestration of the broader immune response. NK cells exist across …

Underlying mechanisms of evasion from NK cells as rationale for improvement of NK cell-based immunotherapies

B Seliger, U Koehl - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer (NK) cells belong to the family of innate immune cells with the capacity to
recognize and kill tumor cells. Different phenotypes and functional properties of NK cells …

The adverse impact of tumor microenvironment on NK-cell

Z Hu, X Xu, H Wei - Frontiers in Immunology, 2021 - frontiersin.org
NK cells are considered an important component of innate immunity, which is the first line of
defensing against tumors and viral infections in the absence of prior sensitization. NK cells …

Tumor-primed NK cells: waiting for the green light

M Sabry, MW Lowdell - Frontiers in Immunology, 2013 - frontiersin.org
The functional impairment of natural killer (NK) cells has been frequently reported in cancer
studies. As one of the central components of host anti-tumor immunity, NK cells exert cellular …

Cancer-induced alterations of NK-mediated target recognition: current and investigational pharmacological strategies aiming at restoring NK-mediated anti-tumor …

AS Chretien, A Le Roy, N Vey, T Prebet… - Frontiers in …, 2014 - frontiersin.org
Despite evidence of cancer immune-surveillance, which plays a key role in tumor rejection,
cancer cells can escape immune recognition through different mechanisms. Thus, evasion …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

E Shin, SH Bak, T Park, JW Kim, SR Yoon… - Frontiers in …, 2023 - frontiersin.org
Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Tricking the balance: NK cells in anti-cancer immunity

J Pahl, A Cerwenka - Immunobiology, 2017 - Elsevier
Natural Killer (NK) cells are classically considered innate immune effector cells involved in
the first line of defense against infected and malignant cells. More recently, NK cells have …

Shaping of NK cell responses by the tumor microenvironment

A Stojanovic, MP Correia, A Cerwenka - Cancer Microenvironment, 2013 - Springer
Natural killer (NK) cells belong to the innate immune system and are potent cytolytic and
cytokine-producing effector cells in response to tumor targets. NK cell based anti-tumor …