In silico identification of lead compounds for Pseudomonas aeruginosa PqsA enzyme: Computational study to block biofilm formation

M Shahab, M Danial, T Khan, C Liang, X Duan… - Biomedicines, 2023 - mdpi.com
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium implicated in acute
and chronic nosocomial infections and a leading cause of patient mortality. Pseudomonas …

Rational Drug Design for Pseudomonas aeruginosa PqsA Enzyme: An in silico Guided Study to Block Biofilm Formation

B Shaker, S Ahmad, TD Thai, S Eyun… - Frontiers in molecular …, 2020 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic gram-negative bacterium implicated in acute
and chronic nosocomial infections and a leading cause of patient mortality. Such infections …

Investigation of Pseudomonas aeruginosa quorum-sensing signaling system for identifying multiple inhibitors using molecular docking and structural analysis …

V Soheili, BSF Bazzaz, N Abdollahpour… - Microbial …, 2015 - Elsevier
Pseudomonas aeruginosa is an opportunistic human pathogen and a common Gram-
negative bacterium in hospital-acquired infections. It causes death in many burn victims …

Drug Repurposing Targeting Pseudomonas aeruginosa MvfR Using Docking, Virtual Screening, Molecular Dynamics, and Free-Energy Calculations

TF Vieira, RP Magalhães, M Simões, SF Sousa - Antibiotics, 2022 - mdpi.com
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium responsible for
acute and chronic infections in planktonic state or in biofilms. The sessile structures are …

In silico identification of novel PqsD inhibitors: promising molecules for quorum sensing interference in Pseudomonas aeruginosa

TF Vieira, NM Cerqueira, M Simões… - … Systems Design & …, 2024 - pubs.rsc.org
PqsD is an anthraniloyl-CoA anthraniloyltransferase involved in the synthesis of the
secondary metabolites essential to the formation of Pseudomonas quinolone signal (PQS) …

Combined machine learning and pharmacophore based virtual screening approaches to screen for antibiofilm inhibitors targeting LasR of Pseudomonas aeruginosa

A Vetrivel, J Ramasamy, S Natchimuthu… - Journal of …, 2023 - Taylor & Francis
Pseudomonas aeruginosa, a virulent pathogen affects patients with cystic fibrosis and
nosocomial infections. Quorum sensing (QS) mechanism plays a crucial role in causing …

Virtual Screening of FDA-Approved Drugs against LasR of Pseudomonas aeruginosa for Antibiofilm Potential

S Sadiq, NF Rana, MA Zahid, MK Zargaham… - Molecules, 2020 - mdpi.com
Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that is present
commonly in soil and water and is responsible for causing septic shock, pneumonia, urinary …

[HTML][HTML] Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies

AS Tajani, ZA Tehranizadeh… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Objective (s): Biofilm-associated infections are challenging to manage or treat since the
biofilm matrix is impenetrable to most antibiotics. Therefore, the best approach to deal with …

In Vitro Assessment on Designing Novel Antibiofilms of Pseudomonas aeruginosa Using a Computational Approach

D Rachmawati, MZ Fahmi, MI Abdjan, EB Wasito… - Molecules, 2022 - mdpi.com
An anti-biofilm that can inhibit the matrix of biofilm formation is necessary to prevent
recurrent and chronic Pseudomonas aeruginosa infection. This study aimed to design …

Molecular docking, quorum quenching effect, antibiofilm activity and safety profile of silver-complexed sulfonamide on Pseudomonas aeruginosa

FS Siqueira, CFS Alves, AK Machado, JD Siqueira… - Biofouling, 2021 - Taylor & Francis
Microbial infections caused by sessile microorganisms are known to be a more challenging
issue than infections caused by the same microorganisms in the planktonic state …