The analysis and description of the appearance of cell death in tissue sections can add
valuable information to research studies. The scoring/grading and quantification of cell …

BACKGROUND The Cell Death Nomenclature Committee (members: Thomas Bucci,
Samuel Cohen, Andrew Fix, Jerry Hardisty, Stuart Levin, Edward LeGrand, Robert …

Different types of cell death are often defined by morphological criteria, without a clear
reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death …

Apoptosis can be defined as a carefully regulated process, characterized by specific
morphologic and biochemical features. It is initiated by both physiologic and pathologic …

Histopathologic scoring is a tool by which semiquantitative data can be obtained from
tissues. Initially, a thorough understanding of the experimental design, study objectives, and …

Historically, there has been confusion relating to the diagnostic nomenclature for individual
cell death. Toxicologic pathologists have generally used the terms “single cell necrosis” and …

With increasing importance of apoptosis, many assays have been developed to detect
apoptosis in cell populations and individual cells. Apoptotic cells are often proved using …

Objective–To review the human and veterinary literature on the biology of apoptosis in
health and disease. Data Sources–Data were examined from the human and veterinary …

Publisher Summary Applications of cytometry in necrobiology have two goals (1) to
elucidate molecular mechanisms associated with cell death and (2) to assay viability of …

Apoptosis was the first programmed cell death to be defined—highly regulated and
immunologically silent, as apoptotic bodies are being removed without triggering …