ABSTRACT Introduction: Drug-drug interactions (DDIs) continue to account for 5% of
hospital admissions and therefore remain a major regulatory concern. Effective, quantitative …

The importance of transporter-mediated drug–drug interaction (TP-DDI) has been rapidly
recognized by the recent publication of its clinical evidences and subsequent updated …

To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a
model to characterize transport kinetics for in vivo pharmacokinetic prediction, the …

Comprehensive characterization of transporter mediated drug‐drug interactions (DDIs) is
important to formulate clinical management strategies and ensure the safe and effective use …

Transporter‐mediated drug–drug interactions are one of the major mechanisms in
pharmacokinetic‐based drug interactions and correspondingly affecting drugs' safety and …

Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …

Introduction Transporters are significant in dictating drug pharmacokinetics, thus inhibition of
transporter function can alter drug concentrations resulting in drug-drug interactions (DDIs) …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

Many drug–drug interactions (DDI s) are based on alterations of the plasma concentrations
of a victim drug due to another drug causing inhibition and/or induction of the metabolism or …

Recent studies of membrane transporters have revealed their importance in determining the
pharmacokinetics of transporter substrates. When drug-drug interactions (DDIs) or genetic …