Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans
is important to reduce the risk of failure during drug development. In addition, when …

Introduction: Human pharmacokinetic (PK) prediction can be a significant challenge to drug
candidates undergoing transporter-mediated clearance, when only animal data and in vitro …

Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …

The past few years have ushered in a wealth of new information on transporter biology,
ranging from the publication of new crystal structures of the human glucose transporters …

Computational modeling has advanced our understanding of drug absorption, tissue
distribution, excretion and toxicity profiles by providing both direct and indirect knowledge of …

Solute carrier (SLC) transporters present as the loci of important drug–drug interactions
(DDIs). Therefore, sponsors generate in vitro half‐maximal inhibitory concentration (IC50) …

The hypothesis that cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) played
complementary roles in drug absorption and disposition was first proposed 15 years ago. 1 …

Therapeutics in 2001, the National Institutes of Health Biomarkers Definitions Working
Group provided an early definition of a biomarker as “a characteristic that is objectively …

Drug transporters are recognized widely for their role in clinical pharmacokinetics and drug–
drug interactions (DDIs). This has provided impetus to the inclusion of transporter substrate …