Defining cellular and molecular identities within the kidney is necessary to understand its
organization and function in health and disease. Here we demonstrate a reproducible …

Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …

The function of each renal tubule segment depends on the genes expressed therein. High-
throughput methods used for global profiling of gene expression in unique cell types have …

Background Proximal tubule cells dominate the kidney parenchyma numerically, although
less abundant cell types of the distal nephron have disproportionate roles in water and …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists …

Bulk-tissue RNA-Seq is increasingly being used in the study of physiological and
pathophysiological processes in the kidney; however, the presence of multiple cell types in …

Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …

Background A challenge for single-cell genomic studies in kidney and other solid tissues is
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …

Diabetic nephropathy is characterized by damage to both the glomerulus and
tubulointerstitium, but relatively little is known about accompanying cell-specific changes in …

Recent techniques for single-cell RNA sequencing (scRNA-seq) at high throughput are
leading to profound new discoveries in biology. The ability to generate vast amounts of …