The deployment of effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID …
Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
Memory B cells play a fundamental role in host defenses against viruses, but to date, their role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
JS Turner, JA O'Halloran, E Kalaidina, W Kim… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 mRNA-based vaccines are about 95% effective in preventing COVID- 19 1, 2, 3, 4, 5. The dynamics of antibody-secreting plasmablasts and germinal centre B …
Protective immunity against COVID-19 likely depends on the production of SARS-CoV-2– specific plasma cells and memory B cells postinfection or postvaccination. Previous work …
E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current global pandemic, it is time to analyze the evolution of the immune protection that infection …
J Pušnik, E Richter, B Schulte, R Dolscheid-Pommerich… - Cell Reports, 2021 - cell.com
Memory B cells seem to be more durable than antibodies and thus crucial for the long-term immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
Y Zurbuchen, J Michler, P Taeschler, S Adamo… - Nature …, 2023 - nature.com
The B cell response to different pathogens uses tailored effector mechanisms and results in functionally specialized memory B (Bm) cell subsets, including CD21+ resting, CD21 …
Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2– specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …