Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 5
million deaths worldwide. Multiple reports indicate that the endothelium is involved during …

Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …

Acute lung injury (ALI) leading to acute respiratory distress syndrome is the major cause of
COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the interaction between its surface …

Background. Emerging evidences suggest that in severe COVID-19, multi-organ failure is
associated with a hyperinflammatory state (the so-called “cytokine storm”) in combination …

Currently, the world is suffering from the pandemic of coronavirus disease 2019 (COVID-19),
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Angiotensin
converting enzyme 2 (ACE2) receptor present on the cell surface to enter cells. Angiotensin …

ABSTRACT SARS-CoV-2 infection can cause compromised respiratory function and
thrombotic events. SARS-CoV-2 binds to and mediates downregulation of angiotensin …

The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can
interact with endothelial cells. However, no studies demonstrated the direct effect of the …

Abstract COVID-19, caused by SARS-CoV-2, is a respiratory disease associated with
inflammation and endotheliitis. Mechanisms underling inflammatory processes are unclear …

Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the
lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory …