Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …

INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Most common genetic risk variants associated with neuropsychiatric disease are noncoding
and are thought to exert their effects by disrupting the function of cis regulatory elements …

Joint profiling of chromatin accessibility and gene expression from the same single cell
provides critical information about cell types in a tissue and cell states during a dynamic …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Cellular heterogeneity in the human brain obscures the identification of robust cellular
regulatory networks, which is necessary to understand the function of non-coding elements …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Abstract Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq)
accurately depicts the chromatin regulatory state and altered mechanisms guiding gene …

Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …

Single-cell technologies enable measure of unique cellular signatures, but are typically
limited to a single modality. Computational approaches allow integration of diverse single …