Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …

Highlights•The genetic liability of schizophrenia is established as polygenic.•Schizophrenia
risk alleles converge onto specific synaptic gene-sets.•Schizophrenia shares risk alleles with …

There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

Schizophrenia alters basic brain processes of perception, emotion, and judgment to cause
hallucinations, delusions, thought disorder, and cognitive deficits. Unlike neurodegeneration …

Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …

The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …