Prevention of noise-induced hearing loss: potential therapeutic agents

CG Le Prell, J Bao - Noise-induced hearing loss: Scientific advances, 2012 - Springer
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. The
development of novel therapeutic agents to reduce NIHL would increase the potential …

Emerging therapeutic interventions against noise-induced hearing loss

SH Sha, J Schacht - Expert opinion on investigational drugs, 2017 - Taylor & Francis
Introduction: Noise-induced hearing loss (NIHL) due to industrial, military, and recreational
noise exposure is a major, but also potentially preventable cause of acquired hearing loss …

Emerging treatments for noise-induced hearing loss

N Oishi, J Schacht - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Approximately 5% of the population worldwide suffers from industrial, military or
recreational noise-induced hearing loss (NIHL) at a great economic cost and detriment to …

Pharmacological agents used for treatment and prevention in noise-induced hearing loss

MS Sakat, K Kilic, S Bercin - European Archives of Oto-Rhino-Laryngology, 2016 - Springer
Noise is a stress factor that causes auditory, psychological and physiological effects. The
realization that sudden loud noises or chronic exposure to noise in social and working …

Compounds for the prevention and treatment of noise-induced hearing loss

ED Lynch, J Kil - Drug discovery today, 2005 - Elsevier
Noise-induced hearing loss (NIHL) is the leading occupational disease and a major
contributor to the development of age-related hearing loss. The pharmacological prevention …

Drug development for noise-induced hearing loss

I Varela-Nieto, S Murillo-Cuesta, M Calvino… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Excessive exposure to noise is a common occurrence that contributes to
approximately 50% of the non-genetic hearing loss cases. Researchers need to develop …

Prevention of noise-induced hearing loss using investigational medicines for the inner ear: Previous trial outcomes should inform future trial design

CG Le Prell - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: Noise-induced hearing loss (NIHL) is an important public health issue resulting
in decreased quality of life for affected individuals, and significant costs to employers and …

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

CG Le Prell, D Yamashita, SB Minami, T Yamasoba… - Hearing research, 2007 - Elsevier
Recent research has shown the essential role of reduced blood flow and free radical
formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and …

Noise-induced hearing loss and its prevention: Current issues in mammalian hearing

CG Le Prell, TA Hackett, R Ramachandran - Current opinion in physiology, 2020 - Elsevier
Highlights•Noise-induced hearing loss (NIHL) remains a major public health issue.•Studies
in animal models show that both sensory hair cells and cochlear synapses are vulnerable to …

Pharmacological approaches to the prevention and treatment of cochlear injury due to noise

RD Kopke - Audiological Medicine, 2007 - Taylor & Francis
Sensorineural hearing loss (SNHL) due to the damaging effects of noise is the second
leading cause of SNHL, next to presbyacusis, in the industrialized world. It is the leading …