A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein
Y Li, Y Wan, P Liu, J Zhao, G Lu, J Qi, Q Wang, X Lu… - Cell research, 2015 - nature.com
Abstract The newly-emerging Middle East respiratory syndrome coronavirus (MERS-CoV)
can cause severe and fatal acute respiratory disease in humans. Despite global efforts, the …
can cause severe and fatal acute respiratory disease in humans. Despite global efforts, the …
Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27
X Yu, S Zhang, L Jiang, Y Cui, D Li, D Wang, N Wang… - Scientific reports, 2015 - nature.com
Abstract The recently reported Middle East respiratory syndrome coronavirus (MERS-CoV)
causes severe respiratory illness in humans with an approximately 30% mortality rate. The …
causes severe respiratory illness in humans with an approximately 30% mortality rate. The …
A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike …
L Du, G Zhao, Y Yang, H Qiu, L Wang, Z Kou… - Journal of …, 2014 - Am Soc Microbiol
Prophylactic and therapeutic strategies are urgently needed to combat infections caused by
the newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we …
the newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we …
Advances in MERS-CoV vaccines and therapeutics based on the receptor-binding domain
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus
that was first reported in 2012. The MERS-CoV genome encodes four major structural …
that was first reported in 2012. The MERS-CoV genome encodes four major structural …
A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses …
An emerging respiratory infectious disease with high mortality, Middle East respiratory
syndrome (MERS), is caused by a novel coronavirus (MERS-CoV). It was first reported in …
syndrome (MERS), is caused by a novel coronavirus (MERS-CoV). It was first reported in …
Structural definition of a neutralization-sensitive epitope on the MERS-CoV S1-NTD
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into the human
population in 2012 and has caused substantial morbidity and mortality. Potently neutralizing …
population in 2012 and has caused substantial morbidity and mortality. Potently neutralizing …
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
I Widjaja, C Wang, R van Haperen… - Emerging microbes & …, 2019 - Taylor & Francis
ABSTRACT The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic
virus that causes severe and often fatal respiratory disease in humans. Efforts to develop …
virus that causes severe and often fatal respiratory disease in humans. Efforts to develop …
Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on the Middle East respiratory syndrome coronavirus spike glycoprotein to avoid …
Middle East respiratory syndrome coronavirus (MERS-CoV) causes a highly lethal
pulmonary infection with∼ 35% mortality. The potential for a future pandemic originating …
pulmonary infection with∼ 35% mortality. The potential for a future pandemic originating …
Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
H Zhou, Y Chen, S Zhang, P Niu, K Qin, W Jia… - Nature …, 2019 - nature.com
Most neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-
CoV) target the receptor-binding domain (RBD) of the spike glycoprotein and block its …
CoV) target the receptor-binding domain (RBD) of the spike glycoprotein and block its …
Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus
ABSTRACT The newly emerged Middle East respiratory syndrome coronavirus (MERS-
CoV) has infected at least 77 people, with a fatality rate of more than 50%. Alarmingly, the …
CoV) has infected at least 77 people, with a fatality rate of more than 50%. Alarmingly, the …
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