Phylogenetic analysis of the endoribonuclease Dicer family
Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved
in regulation of gene expression at the post-transcriptional level. Dicers are conserved from …
in regulation of gene expression at the post-transcriptional level. Dicers are conserved from …
RNA interference of an orthologue of Dicer of Meloidogyne incognita alludes to the gene's importance in nematode development
Dicers and dicer-like enzymes play an essential role in small RNA processing in eukaryotes.
Nematodes are thought to encode one dicer, DCR-1; only that for Caenorhabditis spp. is …
Nematodes are thought to encode one dicer, DCR-1; only that for Caenorhabditis spp. is …
Genetic insight into the domain structure and functions of dicer-type ribonucleases
K Ciechanowska, M Pokornowska… - International journal of …, 2021 - mdpi.com
Ribonuclease Dicer belongs to the family of RNase III endoribonucleases, the enzymes that
specifically hydrolyze phosphodiester bonds found in double-stranded regions of RNAs …
specifically hydrolyze phosphodiester bonds found in double-stranded regions of RNAs …
Multiple Dicer Genes in the Early-Diverging Metazoa
Dicer proteins are highly conserved, are present in organisms ranging from plants to
metazoans, and are essential components of the RNA interference pathway. Although the …
metazoans, and are essential components of the RNA interference pathway. Although the …
The molecular architecture of human Dicer
Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes.
Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas …
Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas …
The Significance of the DUF283 Domain for the Activity of Human Ribonuclease Dicer
A Szczepanska, M Wojnicka… - International Journal of …, 2021 - mdpi.com
Dicers are multidomain proteins, usually comprising an amino-terminal putative helicase
domain, a DUF283 domain (domain of unknown function), a PAZ domain, two RNase III …
domain, a DUF283 domain (domain of unknown function), a PAZ domain, two RNase III …
Overexpression and purification of Dicer and accessory proteins for biochemical and structural studies
NK Sinha, BL Bass - Methods, 2017 - Elsevier
The Dicer family of ribonucleases plays a key role in small RNA-based regulatory pathways
by generating short dsRNA fragments that modulate expression of endogenous genes, or …
by generating short dsRNA fragments that modulate expression of endogenous genes, or …
A glimpse of “Dicer Biology” through the structural and functional perspective
S Paturi, MV Deshmukh - Frontiers in molecular biosciences, 2021 - frontiersin.org
The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …
An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei
H Shi, C Tschudi, E Ullu - Rna, 2006 - rnajournal.cshlp.org
RNA interference (RNAi) is an evolutionarily conserved gene-silencing pathway that is
triggered by double-stranded RNA (dsRNA). Central to this pathway are two ribonucleases …
triggered by double-stranded RNA (dsRNA). Central to this pathway are two ribonucleases …
Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage
Dicer, an RNase III enzyme, initiates RNA interference by processing precursor dsRNAs into
mature microRNAs and small-interfering RNAs. It is also involved in loading and activation …
mature microRNAs and small-interfering RNAs. It is also involved in loading and activation …